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- Arthroplasty/Joint Replacement
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Richard A. Schneider PhD
BiographyRich Schneider was raised in Maplewood, New Jersey. He graduated from Hampshire College in Amherst, Massachusetts in 1991.? As an undergraduate, he published his first paper, which was on skull evolution among domestic dogs and wild canids, following an Internship at the Smithsonian Institution in Washington, DC. He then received his Master's Degree in 1994 and his Doctoral Degree in 1998 from Duke University in Durham, North Carolina. Both of his graduate thesis projects focused on skeletal development and evolution. Dr. Schneider also studied at the Marine Biological Laboratory in Woods Hole, Massachusetts, and at Cold Spring Harbor Laboratory on Long Island, New York. For his Post-doctoral fellowship, Dr. Schneider was sponsored by a NIH/NIDCR training grant at the University of California, San Francisco (UCSF) beginning in 1998. His Postdoctoral work investigated the molecular and cellular biology of the craniofacial skeleton. In 2001, Dr. Schneider joined the faculty of the Department of Orthopaedic Surgery at UCSF, and in 2004 he was made Director of the Department's Molecular & Cell Biology Laboratory on the Parnassus Heights campus.
- 1/95-8/98: Instructor, Department of Zoology, Duke University, Durham, NC.
- 7/01-5/03: Assistant Adjunct Professor, Department of Orthopaedic Surgery, UCSF.
- 6/03-6/04: Assistant Professor in Residence, Department of Orthopaedic Surgery, UCSF.
- 7/04-6/09: Assistant Professor, Department of Orthopaedic Surgery, UCSF.
- 7/04-Present: Director, Molecular & Cell Biology Lab, Department of Orthopaedic Surgery, UCSF.
- 7/07-6/09: Assistant Professor, Department of Cell & Tissue Biology, UCSF.
- 10/08-6/09: Assistant Professor, Department of Orofacial Sciencesy, UCSF.
- 7/09-6/13: Associate Professor, Department of Orthopaedic Surgery, UCSF.
- 7/09-6/13: Associate Professor, Department of Cell & Tissue Biology, UCSF.
- 7/09-6/13: Associate Professor, Department of Orofacial Sciences, UCSF.
- 7/13-present: Professor, Department of Orthopaedic Surgery, UCSF.
- 7/13-present: Professor, Department of Cell & Tissue Biology, UCSF.
- 7/13-present: Professor, Department of Orofacial Sciences, UCSF.
- 8/87-5/91: B.A., Liberal Arts, Hampshire College, Amherst, MA.
- 6/90-8/90: Internship, Vertebrate Zoology, National Museum of Natural History, Smithsonian Institution, Washington, DC.
- 8/91-5/94: M.Sc., Zoology, Duke University, Durham, NC.
- 6/94-5/98: Ph.D., Zoology, Duke University, Durham, NC.
- 6/95-7/95: Embryology Course, Marine Biological Laboratory, Woods Hole, MA.
- 6/98: Molecular Embryology of the Mouse, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
- 8/98-6/01: Postdoctoral Fellow, Departments of Orthopaedic Surgery, Growth & Development, UCSF.
ResearchDr. Schneider's current research program focuses on molecular and cellular mechanisms underlying development of the musculoskeletal system. He and his lab have been employing an avian chimeric transplantation system to exploit the divergent maturation rates and distinct species-specific anatomies of quail and duck. Specifically, his lab has been exchanging mesenchymal stem cells between quail and duck embryos, which challenges resultant chimeras to assimilate donor versus host-specific differences in growth and morphology. Using this approach, his lab has been identifying genes and signaling interactions that regulate the timing of musculoskeletal tissue differentiation, control size and shape, and which ultimately enable cartilage, bone, and muscle to achieve structural and functional integration. A goal of Dr. Schneider's research is to devise molecular-based therapies for inducing repair and regeneration of musculoskeletal tissues affected by congenital defects, disease, and trauma.
- Fish J, Schneider RA. Neural Crest Cells: Evolution, Development and Disease. P. Trainor (editor). Neural Crest-Mediated Tissue Interactions During Craniofacial Development: The Origins of Species-Specific Pattern. 2014; Chapter 6:101-124.
- Yu J, Jheon AH, Ealba EL, Frank Eames B, Butcher KD, Mak SS, Ladher R, Alliston T, Schneider RA. Evolution of a developmental mechanism: Species-specific regulation of the cell cycle and the timing of events during craniofacial osteogenesis. Dev Biol. 2013 Nov 18. PubMed
- Ealba EL, Schneider RA. A simple PCR-based strategy for estimating species-specific contributions in chimeras and xenografts. Development. 2013 Jul; 140(14):3062-8. PubMed
- Berthet E, Chen C, Butcher K, Schneider RA, Alliston T, Amirtharajah M. Smad3 binds scleraxis and mohawk and regulates tendon matrix organization. J Orthop Res. 2013 Sep; 31(9):1475-83. PubMed
- Tokita M, Nakayama T, Schneider RA, Agata K. Molecular and cellular changes associated with the evolution of novel jaw muscles in parrots. Proc Biol Sci. 2013; 280(1752):20122319. PubMed
- Allon AA, Butcher K, Schneider RA, Lotz JC. Structured bilaminar coculture outperforms stem cells and disc cells in a simulated degenerate disc environment. Spine (Phila Pa 1976). 2012 May 1; 37(10):813-8. PubMed
- Allon AA, Butcher K, Schneider RA, Lotz JC. Structured coculture of mesenchymal stem cells and disc cells enhances differentiation and proliferation. Cells Tissues Organs. 2012; 196(2):99-106. PubMed
- Cooke ME, Allon AA, Cheng T, Kuo AC, Kim HT, Vail TP, Marcucio RS, Schneider RA, Lotz JC, Alliston T. Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Osteoarthritis Cartilage. 2011 Oct; 19(10):1210-8. PubMed
- Mitgutsch C, Wimmer C, SÃ¡nchez-Villagra MR, Hahnloser R, Schneider RA. Timing of ossification in duck, quail, and zebra finch: intraspecific variation, heterochronies, and life history evolution. Zoolog Sci. 2011 Jul; 28(7):491-500. PubMed
- Solem RC, Eames BF, Tokita M, Schneider RA. Mesenchymal and mechanical mechanisms of secondary cartilage induction. Dev Biol. 2011 Aug 1; 356(1):28-39. PubMed
- Zheng L, Zhang Y, He P, Kim J, Schneider R, Bronckers AL, Lyaruu DM, DenBesten PK. NBCe1 in mouse and human ameloblasts may be indirectly regulated by fluoride. J Dent Res. 2011 Jun; 90(6):782-7. PubMed
- Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T. Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-Ã and Runx2 in bone is required for hearing. EMBO Rep. 2010 Oct; 11(10):765-71. PubMed
- He P, Zhang Y, Kim SO, Radlanski RJ, Butcher K, Schneider RA, DenBesten PK. Ameloblast differentiation in the human developing tooth: effects of extracellular matrices. Matrix Biol. 2010 Jun; 29(5):411-9. PubMed
- Tokita M, Schneider RA. Developmental origins of species-specific muscle pattern. Dev Biol. 2009 Jul 15; 331(2):311-25. PubMed
- Allon A, Schneider RA, Lotz JC. SAS Journal. Co-culture of adult mesenchymal stem cells and nucleus pulposus cells in bilaminar pellets for intervertebral disc regeneration. 2009; 2(3):41-49.
- Jheon AH, Schneider RA. The cells that fill the bill: neural crest and the evolution of craniofacial development. J Dent Res. 2009 Jan; 88(1):12-21. PubMed
- Eames BF, Schneider RA. The genesis of cartilage size and shape during development and evolution. Development. 2008 Dec; 135(23):3947-58. PubMed
- Merrill AE, Eames BF, Weston SJ, Heath T, Schneider RA. Mesenchyme-dependent BMP signaling directs the timing of mandibular osteogenesis. Development. 2008 Apr; 135(7):1223-34. PubMed
- Lwigale PY, Schneider RA. Other chimeras: quail-duck and mouse-chick. Methods Cell Biol. 2008; 87:59-74. PubMed
- Derynck R, Piek E, Schneider RA, Choy L, Alliston T. The TGF-Ã Family. Derynck and Miyazono (Editors). Chapter 21: TGF-Ã family signalling in mesenchymal differentiation. 2008; 613-666.
- Eames BF, Allen N, Young J, Kaplan A, Helms JA, Schneider RA. Skeletogenesis in the swell shark Cephaloscyllium ventriosum. J Anat. 2007 May; 210(5):542-54. PubMed
- Schneider RA. How to tweak a beak: molecular techniques for studying the evolution of size and shape in Darwin's finches and other birds. Bioessays. 2007 Jan; 29(1):1-6. PubMed
- Ye L, Le TQ, Zhu L, Butcher K, Schneider RA, Li W, Besten PK. Amelogenins in human developing and mature dental pulp. J Dent Res. 2006 Sep; 85(9):814-8. PubMed
- Haggstrom AN, Lammer EJ, Schneider RA, Marcucio R, Frieden IJ. Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development. Pediatrics. 2006 Mar; 117(3):698-703. PubMed
- Noden DM, Schneider RA. Neural crest cells and the community of plan for craniofacial development: historical debates and current perspectives. Adv Exp Med Biol. 2006; 589:1-23. PubMed
- Schneider RA. Developmental mechanisms facilitating the evolution of bills and quills. J Anat. 2005 Nov; 207(5):563-73. PubMed
- Eames BF, Schneider RA. Quail-duck chimeras reveal spatiotemporal plasticity in molecular and histogenic programs of cranial feather development. Development. 2005 Apr; 132(7):1499-509. PubMed
- Miclau T, Schneider RA, Eames BF, Helms JA. Bone Regeneration and Repair: Biology and Clinical Applications. Lieberman and Friedlaender (Editors). Common molecular mechanisms regulating fetal bone formation and adult fracture repair. 2005; 45-55.
- Radlanski RJ, Renz H, Lajvardi S, Schneider RA. Bone remodeling during prenatal morphogenesis of the human mental foramen. Eur J Oral Sci. 2004 Aug; 112(4):301-10. PubMed
- Helms JA, Schneider RA. Cranial skeletal biology. Nature. 2003 May 15; 423(6937):326-31. PubMed
- Schneider RA, Helms JA. The cellular and molecular origins of beak morphology. Science. 2003 Jan 24; 299(5606):565-8. PubMed
- Radlanski RJ, Renz H, MÃ¼ller U, Schneider RA, Marcucio RS, Helms JA. Eur J Oral Sci. Prenatal morphogenesis of the human mental foramen. 2002; 6(110):452-9.
- Schneider RA, Miclau T, Helms JA. Orthopaedics. Fitzgerald, Kaufer, and Malkani (Editors). Embryology of Bone. 2002; 143-146.
- Schneider RA, Hu D, Rubenstein JL, Maden M, Helms JA. Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH. Development. 2001 Jul; 128(14):2755-67. PubMed
- Cordero D, Schneider RA, Helms JA. Craniofacial Surgery: Science and Surgical Technique. Lin, Ogle, and Jane (Editors). Morphogenesis of the Face. 2001; 75-83.
- Young DL, Schneider RA, Hu D, Helms JA. Genetic and teratogenic approaches to craniofacial development. Crit Rev Oral Biol Med. 2000; 11(3):304-17. PubMed
- Schneider RA. Neural crest can form cartilages normally derived from mesoderm during development of the avian head skeleton. Dev Biol. 1999 Apr 15; 208(2):441-55. PubMed
- Schneider RA, Hu D, Helms JA. From head to toe: conservation of molecular signals regulating limb and craniofacial morphogenesis. Cell Tissue Res. 1999 Apr; 296(1):103-9. PubMed
- Smith KK, Schneider RA. Have gene knockouts caused evolutionary reversals in the mammalian first arch? Bioessays. 1998 Mar; 20(3):245-55. PubMed
- Schneider, RA Helms, JA. Current Opinion in Orthopedics. Development and regeneration of the musculoskeletal system. 1998; 6(9):20-24.
- Coppinger RP, Schneider RA. The Domestic Dog. Serpell J (Editor). Evolution of working dogs. 1995; 21-47.
Grants and Awards
- 1990: Internship Stipend Award. National Museum of Natural History, Smithsonian Institution, Washington, DC.
- 1991: Threshold Grant. Hampshire College, Amherst, MA.
- 1995: Tuition and Stipend Award. Marine Biological Laboratory, Woods Hole, MA.
- 1997-1998: Dissertation Improvement Grant. National Science Foundation, Washington, DC.
- 1998: Tuition and Stipend Award. Cold Spring Harbor Laboratory, NY.
- 1998-2001: Training Grant in Craniofacial Anomalies. NIH/NIDCR.
- 2002-2003: Research Evaluation and Allocation Committee Grant. School of Medicine, UCSF.
- 2002-2005: R03 (Principal Investigator), "The Role of Neural Crest in Facial Patterning." NIH/NIDCR.
- 2002-2003: Academic Senate Individual Investigator Award. UCSF.
- 2004: New Investigator Recognition Award, Best Poster. 50th Annual Meeting of the Orthopaedic Research Society.
- 2004-2006: Basil O'Connor Starter Scholar Award. March of Dimes Birth Defects Foundation.
- 2004-2010: R01 (Principal Investigator), "Temporal Regulation of Cranial Skeletogenesis." NIH/NIDCR.
- 2005-2010: R01 (Co-Investigator), "Intervertebral Disc Repair with Mesenchymal Stem Cells." NIH/NIAMS.
- 2006-2009: R21 (Principal Investigator), "A New System to Study the Control of Epidermal Growth." NIH/NIAMS.
- 2006: Young Investigator Award, Developmental Biology in Orthopaedics Research Symposium, American Academy of Orthopaedic Surgeons, Toronto, Ontario, Canada.
- 2008-2009: Disease Team Planning Award (Co?Investigator), "A CIRM Disease Team for the Regeneration of Cartilage Following Trauma and Arthritis." California Institute for Regenerative Medicine (CIRM).
- 2010-2015: R01 (Principal Investigator), "Mesenchymal Regulation of Osteogenesis." NIH/NIDCR.
Membership & Committees
- 1994-Present: International Society of Vertebrate Morphologists.
- 1996-Present: Society for Developmental Biology.
- 1996-Present: Federation of American Societies for Experimental Biology.
- 1998-Present: Sigma Xi, The Scientific Research Society.
- 2002-Present: American Association for the Advancement of Science.
- 2003-Present: Orthopaedic Research Society.
- 2003-Present: Program in Craniofacial and Mesenchymal Biology (CMB), UCSF.
- 2003-Present: Fundraising and Alumni Relations Committee, Department of Orthopaedic Surgery, UCSF.
- 2004-Present: Society of Craniofacial Genetics.
- 2004-Present: Research Committee, Department of Orthopaedic Surgery, UCSF.
- 2004-Present: Committee on Library, Academic Senate, UCSF.
- 2005-Present: Oral and Craniofacial Sciences (OCS) Graduate Program Faculty Group, UCSF.
- 2005-Present: System-Wide University Committee on Library (UCOL), Academic Senate, University of California.
- 2005-Present: Human Embryonic Stem Cell Biology (hESC) Program, UCSF.
- 2005-Present: Biomedical Sciences (BMS) Graduate Program, UCSF.
- 2005-Present: Faculty Development Committee, Department of Orthopaedic Surgery, UCSF.
- 2005-Present: Communications Committee, Department of Orthopaedic Surgery, UCSF.
- 2006-Present: Tetrad Program in Developmental Biology (Program in Biological Sciences (PIBS)), UCSF.
- 2006-Present: European Society for Evolutionary Developmental Biology.
- 2008-Present: American Association of Anatomists.
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