Current Clinical Trials
Below is a list of ongoing clinical trials that are currently open to enrollment.
Ultrasound in the Treatment of Tibial Fractures (TRUST)
The purpose of this study is to determine the safety and effectiveness of low intensity pulsed ultrasound in the treatment of tibial fractures treated with intramedullary nailing.
If you are interested in participating in this clinical trial, click here.
Optimal Grafting Options for Large Bone Defects of the Tibia (pTOG)
The purpose of this METRC study is to determine if rhBMP-2, a bone graft substitute, is as effective as using bone from the hip (iliac crest autograft) to help promote healing of open, tibia fractures with a bone defect. Read more about the pTOG study here.
If you are interested in participating in this clinical trial, click here.
Optimal Fixation of Open Tibia Fractures (FIXIT)
This METRC study will compare two standard options for treating severe open tibia fractures: internal fixation with a nail or plate and external ring fixation. Read more about the FIXIT study here.
If you are interested in participating in this clinical trial, click here.
BIOBURDEN Study
The primary objective of this study is to characterize the contemporary extremity wound “bioburden” at the time of definitive wound coverage or closure of severe extremity wounds employing new polymerase chain reaction PCR technology. We will also determine the relationship of subsequent infections to the initial bioburden screen as defined by both PCR technology and standard microbiology techniques. Read more about the BIOBURDEN study here.
If you are interested in participating in this clinical trial, click here.
Oral Versus Intravenus Therapy for Surgical Site Infections Following Fracture Treatment (POvIV)
The goal of this study is to investigate the efficacy of oral (par oris – PO) antibiotic therapy versus intravenous (IV) systemic antibiotics in the treatment of acute infection after plate fixation of fractures. Read more about the POvIV study here.
If you are interested in participating in this clinical trial, click here.
Plate Versus Intramedullary Nail Fixation of Proximal Tibia Fractures (IMPRESS)
The two most common methods of fixation for proximal tibia fractures are intramedullary nailing and plate fixation. The purpose of this study is to compare the outcomes of these two techniques.
If you are interested in participating in this clinical trial, click here.
Evaluation of Tibial Plateau Fractures with Quantitative MRI
Post-traumatic osteoarthritis (PTOA) is a disabling condition affecting patients with articular trauma. Several agents now show promise in mitigating the effect of joint injuries and preventing PTOA, but study in humans is limited by the variable latency of the condition and availability of a valid outcome measurement. Recently described magnetic resonance (MR) imaging techniques can quantitatively assess morphology and biochemical changes in cartilage and bone in osteoarthritis of the knee. We are trying to validate MR imaging techniques as a surrogate for joint health and early PTOA after operative treatment of high-energy tibial plateau fracture.
If you are interested in participating in this clinical trial, click here.
DoseAware Study
This study will assess real-time radiation exposure from c-arm fluoroscopy during selected orthopaedic trauma surgeries of the ankle, wrist, hip and tibial plateau. Real-time dosimetry devices, such as DoseAware, may limit radiation exposure during orthopaedic trauma cases that require fluoroscopy.
If you are interested in participating in this clinical trial, click here.
