Directed by Richard J. O’Donnell, M.D., the UCSF Orthopaedic Oncology Service at the UCSF Helen Diller Family Comprehensive Cancer Center strives to provide expert care in terms of diagnosis and management of a wide variety of bone and soft tissue tumors and tumor-like conditions.

Bone conditions commonly treated by Dr. O’Donnell include benign diagnoses such as fibrous dysplasia, osteofibrous dysplasia, enchondroma, giant cell tumor, non-ossifying fibroma, osteoid osteoma, osteoblastoma, osteochondroma, eosinophilic granuloma, simple bone cyst, aneurysmal bone cyst, chondroblastoma, and Paget disease. The malignant bone conditions most frequently seen include secondary lesions resulting from metastatic carcinoma, lymphoma, multiple myeloma, or melanoma. Primary osseous malignancies, which are comparatively rare, include osteosarcoma, Ewing sarcoma, and chondrosarcoma.

Examples of benign soft tissue tumors managed in the UCSF Orthopaedic Oncology Practice include lipoma, desmoid fibromatosis, schwannoma, myxoma, nodular fasciitis, and myositis ossificans. The most common soft tissue malignancies are soft tissue sarcomas, which include subtypes such as pleomorphic undifferentiated sarcoma, myxofibrosarcoma, liposarcoma, synovial sarcoma, rhabdomyosarcoma, leiomyosarcoma, and malignant peripheral nerve sheath sarcoma.