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- Arthroplasty/Joint Replacement
- Basic Research
- Foot & Ankle
- Intervertebral Disc
- Minimally Invasive Surgery
- Orthopaedic Oncology
- Orthotics & Prosthetics
- Skeletal Health
- Sports Medicine
- Stem Cells
- Surgical Navigation/Robotics
- Trauma & Problem Fractures
Providing expert care to patients with a wide variety of bone and soft tissue tumors and tumor-like conditions remains the professional focus of Richard J. O'Donnell, M.D., who serves as Chief of the UCSF Orthopaedic Oncology. Clinical research is directed towards osseointegration as a means of achieving stable endoprosthetic reconstruction for limb salvage patients and transdermal anchorage for amputee patients. Multidisciplinary approaches to management of soft tissue sarcoma patients are also an area of active interest. Educational efforts include teaching of orthopaedic surgical residents and medical students, as well as direction of international conferences.
After receiving undergraduate and medical degrees from Harvard, Dr. O'Donnell completed a general surgery internship at the New England Deaconess Hospital. He was graduated from the Harvard Combined Orthopedic Residency Training Program in Boston and the Musculoskeletal Oncology Fellowship Program at the University of Washington in Seattle. He joined the UCSF Medical Center Faculty in 1998.
- 2002 - Present: Chief, Orthopaedic Oncology Service
- 2010-present: Professor of Clinical Orthopaedic surgery, Department of Orthopaedic Surgery, University of California San Francisco
- 1996 - 2002: Chief, Department of Musculoskeletal Oncology and Senior Physician, Kaiser-Permanente, Northern California
- 1995 - 1996: Acting Instructor, Department of Orthopaedic Surgery, University of Washington School of Medicine
- 1995: Clinical Instructor in Orthopaedic Surgery, Harvard Medical School, Beth Israel Hospital, Boston, MA
- 1985: A.B., Biology, Harvard College
- 1989: M.D., Harvard Medical School
- 1989 - 1990: General Surgery Internship Training Program, New England Deaconess Hospital
- 1990 - 1995: Harvard Combined Orthopaedic Residency Training Program
- 1995 - 1996: Advanced Clinical Experience, Musculoskeletal Oncology, University of Washington Medical Center
Clinical research is directed towards a variety of issues important for adult and pediatric orthopaedic oncology. Major areas of interest include means of prosthetic fixation for massive skeletal reconstructions, multimodal neoadjuvant management of soft tissue sarcomas, and use of bone graft substitutes for treating cystic bone defects.
List of Projects & Funding
Biomet ComPreSs(TM) System Work is focusing upon development of a novel means of fixation for prostheses devices used to reconstruct skeletal defects in cases of tumor resection and failed arthroplasty. By utilizing a high compression pre-stress concept, this implant seeks to avoid the use of long intramedullary stems and cement that have been associated with stress shielding, osteolysis, and ultimate failure. In contrast, the ComPreSs(TM) system provides immediate, rigid fixation that results in bone hypertrophy in response to compression forces. This enhances the success and longevity of limb salvage procedures, especially in young, active individuals. The work is supported by a grant from the Biomet Corporation in Warsaw, Indiana. Multimodal Neoadjuvant Treatment of Soft Tissue Sacomas Arising at a rate of just twenty new cases per year per million people, soft tissue sarcomas remain one the rarest forms of cancer. Fortunately, advances in radiologic imaging, surgery, radiation therapy, and chemotherapy have served to improve local control and overall survival. Work is underway to implement a Northern California regional protocol for the multimodality treatment of children and adults with soft tissue sarcoma. Wide surgical resection and external beam radiation therapy remain the mainstays of treatment. However, high dose rate brachytherapy and intraoperative radiation methods are being used increasingly to apply radiation where it is needed most--- directly to the tumor bed at the time of surgery. For patients younger than 65 with large, deep, high grade tumors, pre-operative or neoadjuvant chemotherapy is also being offered in an attempt not only to treat the tumor itself, but also to decrease the risk of metastatic disease, thereby increasing overall survival. Bone Graft Substitutes for Bone Defects A variety of options are now available for the treatment of bone defects that arise from both benign and malignant processes. Dr. James Johnston has helped to pioneer the use of bone cement for giant cell tumor, as well as the addition of threaded pin "rebar" to reinforce cement in cases of metastatic bone deficiency. For more benign cystic conditions of bone, newer substitutes such as coralline hydroxyapatite, are being utilized. These materials provide a matrix for bone healing while avoiding the potential complications of taking bone graft from the patient or from a bone bank.
- Weisstein, J.S.; Racette, W.; Burnette, P.; and O'Donnell, R.J.: Immediate post-operative prostheses for oncologic above- and below-knee amputations. Presented at the 46th Annual Visiting Professorship of the Leroy C. Abbott Society; 22nd Annual Verne T. Inman Lectureship, San Francisco, CA, May 3, 2001; the American Orthotic and Prosthetic Association Annual Meeting, Reno, NV, June 8, 2001; and the 35th Annual American Orthopaedic Association and Orthopaedic Research and Education Foundation Residents' Conference, Nashville, TN, April 14, 2002.
- Biggs, C.A.; Wara, W.M.; Phillips, T.L.; Johnston, J.O.; O'Donnell, R.J.; Weinberg, V. and Haas-Kogan, D.A.: A Comparison of Pediatric and Adult Desmoid Tumors Treated with Radiation Therapy. Submitted to the 43rd Annual American Society for Therapeutic Radiology and Oncology Meeting, San Francisco, CA, November 4-8, 2001.
- Satcher, R.L., Jr.; O'Donnell, R.J.; and Johnston, J.O.: Reconstruction of the pelvis following resection of tumors about the acetabulum. Presented at the Connective Tissue Oncology Society 7th Annual Scientific Meeting, Palm Beach, FL, November 1-3, 2001.
- Weisstein, J.S.; and O'Donnell, R.J.: Treatment of oncologic bone defects with coralline hydroxyapatite. Presented at the 45th Annual Visiting Professorship of the Leroy C. Abbott Society; 21st Annual Verne T. Inman Lectureship, San Francisco,CA, May 4, 2000; 34th Annual American Orthopaedic Association Residents' Conference, Hershey, PA, April 1, 2001; and the Western Orthopaedic Association 65th Annual Meeting, San Francisco, CA, September 24, 2001.
- O'Donnell, R.J.; Fang, A.S.; Silverstein, R.M.; Martin, D.L.; and Johnston, J.O.: Clinical experience with the ComPreSs? device for endoprosthetic fixation: The first eight years. Presented at the International Society of Limb Salvage Conference, Birmingham, United Kingdom, October 10-12, 2001.
- O'Donnell, R.J.; Fang, A.S.; Silverstein, R.M.; Martin, D.L.; and Johnston, J.O.: Reconstruction of massive proximal tibial defects using the ComPreSs? device for endoprsothetic fixation. Presented at the 46th Annual Visiting Professorship of the Leroy C. Abbott Society; 22nd Annual Verne T. Inman Lectureship, San Francisco, CA, May 4, 2001, and at the International Society of Limb Salvage Conference, Birmingham, United Kingdom, October 10-12, 2001.
- O'Donnell, R.J.; Fang, A.S.; Silverstein, R.M.; Martin, D.L.; and Johnston, J.O.: Recent experience with the ComPreSs? compliant pre-stress fixation device for fixation of oncologic and arthroplasty prostheses. Presented at the Western Orthopaedic Association 65th Annual Meeting, San Francisco, CA, September 24, 2001.
Grants and Awards
- 1997-2000, 2001-2004: American Medical Association Physician's Recognition Award in Continuing Medical Education
- 2000, James M. Morris, M.D. Memorial Award, Honoring the Compassionate Physician
- 1999, "Above and Beyond" Service Award
- Physician Health and Satisfaction Committee, The Permanente Medical Group, Inc.
- 1989, Hewlett-Packard Company Medical Graduate Award
Membership & Committees
- American Academy of Orthopaedic Surgeons (AAOS/ADA Guideline on Antibiotic Prophylaxis for Bacteremia in Patients with Permanent Implants Work Group)
- Amputee Coalition of America
- California Orthopaedic Association
- Connective Tissue Oncology Society
- International Society of Limb Salvage
- Massachusetts Medical Society
- Musculoskeletal Tumor Society
- National Comprehensive Cancer Network (Bone Cancer Panel Member; Soft Tissue Sarcoma Panel Member)
- Orthopaedic Surgical Osseointegration Society (Founder, Board Member)
- The Paget Foundation
- The Sarcoma Alliance (Medical Advisory Board Member)
- The Sarcoma Foundation
- Societe Internationale de Chirurgie Orthopedique et de Traumatologie
- Western Orthopaedic Association (Northern California Chapter, Board Member At Large)