Biography

Professor Jeffrey Lotz, Ph.D. has been the Director of the Orthopaedic Bioengineering Laboratory at UCSF since 1992. Dr. Lotz earned a doctorate degree in Medical Engineering from the Harvard/MIT Division of Health Sciences and Technology, a Masters Degree in Mechanical Engineering Design from Stanford University, and Bachelors of Science in Mechanical Engineering from UC Berkeley. Prior work experience includes medical device design (Stanford Research Institute) and medical device failure evaluation (Failure Analysis Associates). Dr. Lotz is a Member of the NIH Peer Review Committee for Tissue Engineering Grants.

As a principal investigator, Dr. Lotz has procured over $9M in extramural funding for spine-related projects. He has earned several awards for spine research, including the ISSLS Prize (2007), Volvo Award (1998), and the North American Spine Society Award (1993). He serves as a Deputy Editor for the journal Spine, and an Associate Editor for The Spine Journal. He has expertise in spine biomechanics and intervertebral disc biology and has published 100 peer-reviewed journal articles. His laboratory work focuses on identifying mechanisms of intervertebral disc degeneration, exploring tissue engineering approaches for treating low back pain, and the biomechanics of spinal instrumentation.

Career

• 2002 - Present: Professor and Director, Orthopaedic Bioengineering Laboratory, University of California at San Francisco
• 2000 - Present: Faculty, Keck Center for Integrative Neuroscience
• 1993 - Present: Joint Bioengineering Graduate Group Faculty, University of California, San Francisco & Berkeley
• 1998 - 2002: Associate Professor and Director, Orthopaedic Bioengineering Laboratory, University of California, San Francisco
• 1993 - 1998: Assistant Professor and Director, Orthopaedic Bioengineering Laboratory, University of California, San Francisco
• 1991 - 1993: Managing Engineer, Failure Analysis Associates, Menlo Park, CA
• 1989 - 1991: Senior Engineer, Failure Analysis Associates, Menlo Park, CA
• 1987: Instructor, Introductory Mechanics, MIT MITES Program, Massachusetts Institute of Technology, Cambridge, MA
• 1986: Sub-intern, Adult Medicine, Mount Auburn Hospital, Cambridge, MA
• 1980 - 1983: Research/Design Engineer, Stanford Research Institute, Menlo Park, CA

Education

• 1979: BS, Mechanical Engineering, University of California, Berkeley
• 1980: MS, Mechanical Engineering Design, Stanford University
• 1988: PhD, Medical Engineering, Massachusetts Institute of Technology/Harvard Division of Health Science and Technology

Research

Therapeutic Loading of the Intervertebral Disc: This research characterizes a disc-loading regimen that optimizes disc health. Using a combination of mathematical models and a dynamic in vivo mouse model, this research will define a therapeutic loading regimen for the intervertebral disc.

Tissue Biomechanics: This research is focused on developing structure/function relationships for musculoskeletal tissues. The goal is to define dependencies between extracellular matrix content and organization and mechanical function. These relationships will provide the basis for clarifying disease etiology as well as defining targets for therapeutic intervention.

Biomechanics of Orthopaedic Implants: A series of studies are being conducted to characterize biomechanical features of novel devices used in a number of orthopaedic applications. For example, cadaveric models are being used to quantify the efficacy of total disc replacement implants toward restoring spine kinematics. Experimental biomechanics is also being used to characterize and optimize external fixation devices used to stabilize long-bone fractures.

Intervertebral Disc Repair with Mesenchymal Stem Cells: This project tests the ability of bone marrow-derived stem cells to differentiate within the environment of the intervertebral disc and to participate during remodeling and repair. A goal is to produce new techniques for treating degenerated and/or injured discs in humans.

Mesenchymal Stem Cells and Mechanoplasticity: This project examines the potential of stem cells in musculoskeletal tissue engineering as a means to regenerate matrix structure and function. A goal is to define mechanical receptiveness of stem cells as a function of differentiation stage, and to develop techniques for patterning tissues using mechanical cues.

Mouse Disk Regeneration by Injection: This project seeks to increase cell proliferation and matrix synthesis in degenerated disc by injecting growth factors such as Fibroblast Growth Factors (FGF) into the nucleus of mouse tail discs which have undergone compression and degeneration. A goal is to understand the effects of injected growth factors and stem cells in a mouse model in order to aid in the development of effective treatments for humans with degenerated disks.

Animal Models of Intervertebral Disc Degeneration and Low Back Pain: Because disc degeneration is an evolving process in vivo, animal models are necessary to clarify degeneration mechanisms as well as to study novel clinical interventions. Several systems have been developed and characterized via a series of outcome measures that include: biomechanics, imaging, cell biology, and tissue morphology.

Tissue Engineering of Fibrocartilage: This project identifies the mechanical and biologic environment necessary to produce the extracellular matrix found in hydrated soft tissues such as temporomandibular joint (TMJ) and intervertebral disc. A goal is to design interventions for arthritis including clinical interventions and development of tissue engineered constructs for implantation.

Publications

• Rhyu, K-W, Walsh, A., O Neill, C.W., Bradford, D.S., and Lotz, J.C., The short-term effects of electrosurgical ablation on proinflammatory mediator production by intervertebral disc cells in tissue culture, The Spine Journal, in press.
• Rousseau, M.A., Ulrich, J.A., Bass, E.C., Rodriguez, A., Liebenberg, E., Liu, J. and Lotz, J.C., Stab incision for inducing intervertebral disc degeneration in the rat. Spine Journal, in press.
• Court, C., and Lotz, J.C., Biological and mechanical consequences of transient intervertebral disc bending, European Spine Journal, in press.
• Rousseau, M.A., Bradford, D.S., Bertagnoli, R., Hu, S.S., and Lotz, J.C., Disc arthroplasty design influences intervertebral kinematics and facet forces. The Spine Journal, V 6(3), pp 258-22006.
• Wagner, D.R., Reiser, K.M., and Lotz, J.C., Glycation increases human annulus fibrosus stiffness in both experimental measurements and theoretical predictions, Journal of Biomechanics, Vol. 39(6), pp 1021-102006.
• Lotz, J.C. and Ulrich, J.A., Innervation, inflammation, and hypermobility may characterize pathologic disc degeneration: Review of animal model data, Journal of Bone and Joint Surgery, V 88(S2), pp 76-200
• Hsieh, A.H., Wagner, D.R., Cheng, L.Y. and Lotz, J.C., Dependence of mechanical behavior of the murine tail disc on regional material properties: a parametric finite element study, ASME J. Biomech. Eng, Vol. 1pp 1158-112006.
• Rousseau, M-A, Bradford, D.S., Hadi, T.M., Pederson, K.L., and Lotz, J.C., The instant axis of rotation influences facet forces at L5/S1 during flexion/extension and lateral bending. The European Spine Journal, 15(3), pp 299-302006.
• Bass, E.C., Nau, W.H., Diederich, C.J., Libenberg, E., Shu, R., Pellegrino, R., Sutton, J., Attawia, M., Hu, S.S., Ferrier, W.T., Lotz, J.C., Intradiscal thermal therapy does not stimulate biologic remodeling in an in vivo model. Spine, (2), pp 139-12006
• Lotz, J.C., and Kim, A.J., Disc degeneration: why, when, and how. Neurosurg Clin N Am, (4), pp 657-62005.
• Keshari, K.R., Zektzer, A.S., Swanson, M.G., Majumdar, S., Lotz, J.C., Kurhanewicz, J. Characterization of intervertebral disc degeneration by high-resolution magic angle spinning (HR-MAS) spectroscopy. Magn Reson Med, (3), pp 519-52005
• Keshari, K.R., Lotz, J.C., Kurhanewicz, J., and Majumdar, S., Correlation of HR-MAS spectroscopy derived metabolite concentrations with collagen and proteoglycan levels and Thompson grade in the degenerative disc, Spine, (23), pp 2683-262005.
• Yao, W., Hadi, T., Jiang, Y., Lotz, J., Wronski, T.J., and Lane, N.E., Basic fibroblast growth factor improves trabecular bone connectivity and bone strength in the lumbar vertebral body of osteopenic rats, Osteoporosis International, (12), pp 1939-192005.
• Acosta, F.L., Lotz, J., and Ames, C.P., The potential role of mesenchymal stem cell therapy for intervertebral disc degeneration: a critical overview. Neurosurg Focus, (E2005.
• Ananthakrishnan, D., Berven, S., Deviren, V., Cheng, K., Lotz, J.C., Xu, Z., and Puttlitz, C.M., The effect on anterior column loading due to different vertebral augmentation techniques. Clinical Biomechanics, V pp 25-2005.
• Diao, E., Shao, F., Liebenberg, E., Rempel, D., and Lotz, J.C., Carpal tunnel pressure alters median nerve function in a dose-dependent manner: a rabbit model for carpal tunnel syndrome, Journal of Orthopaedic Research, V 23(1), pp 218-22005.
• Kroeber, M. Unglaub, F., Guehring, T., Nerlich, A., Hadi, T., Lotz, J., and Carstens, C., Effects of controlled dynamic disc distraction on degenerated intervertebral discs. Spine V (2), pp 181-12005.
• Puttlitz, C.M., Rousseau, M.A., Zheng, X., Hu, S., Tay, B.K-B., and Lotz, J.C., Intervertebral disc replacement maintains cervical spine kinetics, Spine, V (24), pp2809-282005.
• Lotz, J.C., Animal models of intervertebral disc degeneration: lessons learned. Spine V (23), pp 2742-272004
• An, H.S., Anderson, P.A., Haughton, V.M., Iatridis, J.C., Kang, J.D., Lotz, J.C., Natarajan, R.N., Oegema, T.R., Roughley, P., Setton, L.A., Urban, J.P., Videman, T., Andersson, G.B., Weinstein, J.N., Introduction: disc degeneration summary, Spine, V 29(23), pp 2677-262004
• Majumdar, S., Issever, A.S., Burghart, A., Lotz, J., Arfelli, F., Rigon, L., Heitner, G., Menk, R-H., Diffraction enhanced imaging of articular cartilage and comparison with micro-computed tomography of the underlying bone structure. Eur Radiol, V. pp 1440-142004
• Lotz, J.C. and Diederich, C.J., Point of View, Spine, V (10), pp 1130-112004.
• Bass, E., Ashford, F.A., Segal, M.R., and Lotz, J.C., Biaxial testing of human annulus fibrosus and its implications for a constitutive formulation, Annals of Biomedical Engineering, V 32(9), pp 1233-122004
• Rousseau, M-A., Bass, E.C., and Lotz, J.C., An anterior approach to the lumbar spine of the Sprague-Dawley rat, Lab Animal, V (6), pp 43-2004
• Patel, V.V., Hall, K., Ries, M., Lotz, J., Ozhinsky, E., Lindsey, C., Lu, Y., Majumdar, S., A three-dimensional MRI analysis of knee kinematics, J. Orthop Res, V (2), pp 283-22004.
• Crevensten, G., Walsh, A.J.L., Anathakrishnan, D., Page, P., Wahba, G.M., Lotz, J.C. and Berven, S., Intervertebral disc cell therapy for regeneration: Mesenchymal stem cell implantation in rat intervertebral discs, Annals of Biomedical Engineering, V (3), pp 430-42004
• Puttlitz, C.M., Melcher, R.P., Kleinstueck, F.S., Harms, J., Bradford, D.S. and Lotz, J.C., Stability analysis of craniovertebral junction fixation techniques, JBJS, 86-A (3), pp 561-52004
• Puttlitz, C.M., Deviren, V., Smith, J.A., Kleinstueck, F.S., Tran, Q.N., Thurlow, R.W., Eisele, P., Lotz, J.C., Biomechanics of cervical laminoplasty: kinetic studies comparing different surgical techniques, temporal effects and the degree of level involvement. Eur Spine J, V (3), pp 213-22004.
• Wagner, D.R. and Lotz, J.C., Theoretical model and experimental results for the nonlinear elastic behaviour of human annulus fibrosus, Journal of Orthopaedic Research, V (4), pp 901-902004.
• Rannou, F., Lee, T-S., Zhou, R., Chin, J., Lotz, J.C., Mayoux-Benhamou, M-A., Barbet, J.P., and Shyy, J.Y-J., Intervertebral Disc Degeneration: The Role of the Mitochondrial Pathway in Annulus Fibrosus Cell Apoptosis Induced by Overload, American Journal of Pathology, (3), pp 915-92004
• O Neill, C.W., Liu, J.J., Leibenberg, E., Hu, S.S., Deviren, V., Tay, B. K-B., Chin, C.T., and Lotz, J.C., Percutaneous Plasma Decompression Alters Cytokine Expression in Injured Porcine Intervertebral Discs, The Spine Journal, 4(1), pp 88-92004
• Walsh, A.J.L. and Lotz, J.C., Biological Response of the Intervertebral Disc to Dynamic Loading, Journal of Biomechanics, (3), pp 329-32004
• Walsh, A.J.L., Bradford, D.S.B and Lotz, J.C., In Vivo Growth Factor Treatment of Degenerated Intervertebral Discs, Spine, 29(2), pp 156-12004
• Bass, E.C., Wistrom, E.V., Diederich, C.J., Nau, W.H., Pellegrino, R., Ruberti, J., and Lotz, J.C., Heat-Induced Changes in Porcine Annulus Fibrosus Biomechanics, Journal of Biomechanics, (2): 233-22004.
• Palmer, E.I., and Lotz, J.C., The Compressive Creep Properties of Normal and Degenerated Murine Intervertebral Discs. Journal of Orthopaedic Research, (1): 164-12004.
• Hsieh, A.H. and Lotz, J.C., Prolonged Spinal Loading Induces MMP-2 Activation in Intervertebral Discs, Spine, (16), pp 1781-172003
• Ries, M. D., Suzuki, Y., Renowitzky, G., Lotz, J. C., Barrack, R. L., Bourne, R. B., Rorabeck, C. H., Effect of cementless bowed stem distal surface contour and coronal slot on femoral bone strains and torsional stability, J. Arthroplasty, (4), pp 494-492003
• Soejima, O., Diao, E., Lotz, J. C., Hariharan, J. S., Naito, M., Dorsal and Palmar Material Properties of the Adult Human Flexor Profundus Tendon in Zone II, J. Hand Surgery, 8 (1), pp 53-2003
• Kleinstueck, F.S., Diederich, C.J., Nau, W.H., Puttlitz, C.M., Smith, J.A., Bradford, D.S., and Lotz, J.C., Temperature and Thermal Dose Distributions during Intradiscal Electro-Thermal (IDET) Therapy in Cadaveric Lumbar Spine, Spine, (15), pp 1700-1702003
• Whyne, C.M, Hu, S.S. and Lotz, J.C., Burst fracture in the metastatically involved spine, Part II: Biomechanically derived guideline equations for risk prediction, Journal of Spinal Disorders, (2), pp 180-12003
• Ishiko, T., Puttlitz, C.M., Lotz, J.C., and Diao, E., Scaphoid kinematic behavior after division of the transverse carpal ligament, J. Hand Surgery, (2), pp 267-22003
• Whyne, C.M, Hu, S.S. and Lotz, J.C., Burst fracture in the metastatically involved spine. Part I: Development, validation, and parametric analysis of a three-dimensional poroelastic finite element model, Spine, (7), 652-62003
• Issever A.S., Walsh A., Lu Y., Burghardt A., Lotz J.C., and Majumdar S., MicroCT Evaluation of Trabecular Bone Structure In Loaded Murine Tail Vertebrae, Spine 28(2): 123-1Jan 2003
• Lotz, J.C., Hsieh, A.H., Walsh, A.L., Palmer, E.I. and Chin, J.R., Mechanobiology of the Intervertebral Disc, Biochemical Journal, (6), 853-82002
• Melcher, R.P., Puttlitz, C.M., Kleinstueck, F.S., Lotz, J.C., Harms, J., and Bradford, D.S., Biomechanical testing of posterior atlantoaxial fixation techniques, Spine Vol. No. pp 2435-242002.
• Byl, C., Puttlitz, C., Byl, N., Lotz, J., and Topp, K., Strain in the Median and Ulnar Nerves During Upper Extremity Positioning, J. of Hand Surgery, Vol. 27A, No.pp 1032-102002.
• Mao, J.R., Dean, W.B., Taylor, G., Wagner, D.W., Afzal, V., Lotz, J.C., Rubin, E.M., and Bristow, J.D., Tenascin-X Deficiency Mimics the Ehlers-Danlos Syndrome in Mice Through Alteration of Collagen Deposition, Nat Genet. 2002 Apr;30(4):421-5.
• Kroeber M, Ries MD, Suzuki Y, Renowitzky G, Ashford F, Lotz J., Impact Biomechanics and Pelvic Deformation During Insertion of Press Fit Acetabular Cups, Journal of Arthroplasty, J Arthroplasty. 2002 Apr;17(3):349-54.
• Riches P, Dhillon N, Lotz J, Woods A, McNally D, The internal mechanics of the intervertebral disc under cyclic loading., J Biomech. 2002 Sep;35(9):1263.
• Kroeber MW, Rovinsky D, Lotz J, Carstens C., Bioabsorbable materials for fixation of slipped capital femoral epiphysis (SCFE), Orthopade 2002 Jun;31(6):563-7
• Whyne, C.M, Hu, S.S. and Lotz, J.C., Mechanics of Metastatically Involved Spine Described through Poroelastic Modeling, Journal of Biomechanics, 1317-132001
• Kleinstueck, F.S., Diederich, C.J., Nau, W.H., Puttlitz, C.M., Smith, J.A., Bradford, D.S., and Lotz, Acute Biomechanical and Histological Effects of Intradiscal Electrothermal Therapy on Human Lumbar Discs, Spine, 26:2198-2202001
• Chiu, E.J., Newitt, D.C., Segal, M.R., Hu, S.S., Lotz, J.C., Majumdar, S., Measurement of MR Relaxation and Water Diffusion in the Human Lumbar Intervertebral Disc under Compression - In Vitro, Spine. 2001 Oct 1;26(19):E437-44.
• Court, C. Colliou, O.K., Chin, J.R., Liebenberg, E., Bradford, D.S., and Lotz, J.C., The Effect of Static in vivo Bending on the Intervertebral Disc, The Spine Journal, 1 (4): 239-22001
• Dhillon, N., Bass, E.C., and Lotz, J.C., Effect of Frozen Storage on Creep Behavior of Human Intervertebral Discs, Spine, (8): 883-82001
• Diederich, C.J., Nau, W.H., Kleinstueck, F., Lotz J.C., Bradford D.S., IDTT therapy in cadaveric lumbar spine: temperature and thermal dose distributions, in Thermal Treatment of Tissue: Energy Delivery and Assessment, Proceedings of SPIE Annual Meeting, San Jose, Jan 21-2001
• Kroeber MW, Lane N, Lotz JC, Thomsen M, Effects of early estrogen replacement therapy on bone stability of ovariectomized rats. A biomechanical and radiologic study of the tibial plateau, Orthopade. 2000 Dec;29(12):1082-7.
• Fujita, Y., Wagner, D.R., Biviji, A.A., Duncan, N.A., and Lotz, J.C. Anisotropic Shear Behavior of the Annulus Fibrosus: Effect of Harvest Site and Tissue Pre-strain, Medical Engineering & Physics, (5): 349-32000
• Whyne, C.M., Hu, S.S. and Lotz, J.C., Biphasic Material Properties of Lytic Bone Metastases, Annals of Biomedical Engineering, (9): 1154-112000
• Chin, J.R. and Lotz, J.C., Intervertebral Disc Cell Death is Dependent on the Magnitude and Duration of Spinal Loading, Spine, (12): 1477-142000
• Lotz, J.C., Kroeber, M.W., Heilmann, M., Pericherla, K., Kimmel, D., Kinney, J.H., and Lane, N.E., Tibial Plateau Fracture is a Sensitive Measure of Estrogen-Dependent Bone Fragility in Rats, Journal of Orthopaedic Research, (2):326-32000.
• Klisch, S.A., and Lotz, J.C., A special theory of biphasic mixtures and experimental results for human annulus fibrosus tested in confined compression, J. Biomech Eng, Vol. 1pp1-2000
• Filvaroff E; Erlebacher A; Ye J; Gitelman SE; Lotz J; Heillman M; Derynck R. Inhibition of TGF-b receptor signaling in osteoblasts leads to decreased bone remodeling and increased trabecular bone mass, Development, Oct;126(19):4267-1999
• Diao E, Soejima O, Lotz J, Hariharan J. Randomized biomechanical study of zone II human flexor tendon repairs [letter], J Hand Surg [Am], Jul;24(4):871-1999
• Klisch, S.M. and Lotz, J.C., A Fiber-reinforced Continuum Theory and Constitutive Equation for the Annulus Fibrosus, Journal of Biomechanics, (10), pp 1027-101999.
• Randall RL; Wolf EM; Heilmann MR; Lotz J., Comparison of bone-patellar tendon-bone interference screw fixation and hamstring transfemoral screw fixation in anterior cruciate ligament reconstruction , Orthopedics, Jun;22(6):587-1999
• Lotz, J.C., Colliou, O.K., Chin, J.R., Duncan, N.A., and Liebenberg E., Compression-Induced Degeneration of the Intervertebral Disc: An In Vivo Mouse Model and Finite Element Study, Volvo Award for Low Back Pain Research, Spine, Dec 23(23):2493-501998
• Lotz, J.C., The Biomechanics of Prevention and Treatment for Low Back Pain: 2nd International Workshop, Clinical Biomechanics, 561-51998
• Duncan, N.A., and Lotz, J.C., Experimental Validation of a Porohyperelastic Finite Element Model of the Annulus Fibrosus, Biomechanics & Biomedical Engineering, Eds. J. Middleton and G.N. Pande, Gordon and Breach, 1998
• Tay, B. K-B, Le, A.X., Heilman, M., Lotz, J.C., and Bradford, D.S., Use of a Collagen-Hydroxyapatite Matrix in Spinal Fusion: A Rabbit Model, Spine, Nov 1;23(21):2276-19
• Lotz, J.C., Hariharan, J.S., Diao, E., An Analytic Model to Predict the Strength of Tendon Repairs, Journal of Orthopaedic Research, (4): 399-401998.
• Glazer, P.A., Heilmann, M.R., Lotz, J.C., Bradford. D.S., Use of Ultrasound in a Spinal Fusion: A Rabbit Model., Spine, Vol. No. pp 1142-111998
• Whyne, C., Hu, S.S., Lotz, J.C., The Influence of the Posterior Arch on Vertebral Body Strain., Spine, (8): 899-901998
• Fujita, Y., Duncan, N.A., Lotz, J.C., Radial Tensile Properties of the Annulus Fibrosus, Journal of Orthopaedic Research, (15):814-81997
• Glazer, P.A., Heilmann, M.R., Lotz, J.C., Bradford. D.S., Use of Electromagnetic Fields in a Spinal Fusion: A Rabbit Model., Spine, Oct 15;22(20):2351-1997
• Bass, E., Duncan, N.A., Bueff, H.U., Dusic, J., and Lotz, J.C., The Compressive Creep Behavior of the Porcine Intervertebral Disc is Affected by Frozen Storage. Spine,15;22(24):2867-281997
• Lotz, J.C., Hu, S.S., Chiu, D.F., Colliou, O., Glazer, P.A., Duncan, N.A., Poser, D.V.M., Carbonated Apatite Cement Augmentation of Pedicle Screw Fixation in the Lumbar Spine., Spine, Spine, (23):2716-271997
• Hariharan, J.S., Diao, E., Soejima, O. and Lotz, J.C., Tensile Properties of Incomplete Lacerations of the Human Digital Flexor Tendon. The Journal of Hand Surgery, (6): 1-1997.
• Glazer, P.A., Colliou, O., Klisch, S.M., Bradford D.S., Bueff, H.U., Lotz, J.C., Biomechanical Analysis of Multi-Level Fixation Methods in the Lumbar Spine, Spine, (2):171-11997.
• Majumdar, S; Newitt, D; Mathur, A; Osman, D; Gies, A; Chiu, E; Lotz, J; Kinney, J; Genant, H. Magnetic resonance imaging of trabecular bone structure in the distal radius: relationship with X-ray tomographic microscopy and biomechanics. Osteoporosis International, 6(5):376-1996.
• Glazer, P.A., Colliou, O., Lotz, J.C., and Bradford, D.S., Biomechanical Analysis of Lumbosacral Fixation. Spine, (10):1211-121996
• Diao, E., Hariharan, J.S., Soejima, O., and Lotz, J.C. Effect of Peripheral Suture Depth on Strength of Tendon Repairs. The Journal of Hand Surgery, 21A(2), pp243-21996.
• Lotz, J.C. and Namba, R.N., Biomechanics of femoral prostheses. Portland Bone Symposium. Portland OR, August, 1995
• Soejima O; Diao E; Lotz JC; Hariharan JS. Comparative mechanical analysis of dorsal versus palmar placement of core suture for flexor tendon repairs. Journal of Hand Surgery. American Volume, 19Sep, 20(5):801-7
• Bueff HU; Lotz JC; Colliou OK; Khapchik V; Ashford F; Hu SS; Bozic K; Bradford DS. Instrumentation of the cervicothoracic junction after destabilization. Spine, 19Aug 20(16):1789-92
• Lotz, J.C., Cheal, E.J. and Hayes, W.C., Stress Distributions within the Proximal Femur During Gait and Falls: Implications for Osteoporotic Fracture. Osteoporosis International, 195(4):252-61
• Genant, H.K., Gluer, C.C, and Lotz, J.C.: Gender Differences in Bone Density, Skeletal Geometry, and Fracture Biomechanics. Radiology, 190:636-640,1994.
• Lotz, J.C., Cheal E.J., and Hayes W.C.: Fracture Prediction for the Proximal Femur Using Finite Element Models, Part I: Linear Analysis, Journal of Biomechanical Engineering, Vol. 113(4), p. 353-31991.
• Lotz, J.C., Cheal E.J., and Hayes W.C.: Fracture Prediction for the Proximal Femur Using Finite Element Models, Part II: Nonlinear Analysis, Journal of Biomechanical Engineering, Vol. 113(4), p. 361-31991.
• Lotz J.C., Hayes W.C.: Mechanical Properties of Metaphyseal Bone in the Proximal Femur, J. Biomechanics Vol. No. pp. 317-31991.
• Lotz, J.C., Gerhart, T.N., and Hayes, W.C.: Mechanical Properties of Trabecular Bone from the Proximal Femur: A Quantitative CT Study, Journal of Computer Assisted Tomography, 14(107-11990.
• Lotz, J.C. and Hayes, W.C.: The Use of Quantitative Computed Tomography to Estimate Risk of Fracture of the Hip from Falls, The Journal of Bone and Joint Surgery, Vol. 72-A, No. 1990.
• Esses, S.I., Lotz, J.C. and Hayes, W.C.: Biomechanical Properties of the Proximal Femur Determined In Vitro by Single-Energy Quantitative Computed Tomography, Journal of Bone and Mineral Research, Vol. No. 1989
• Cheal, E.J., Lotz, J.C., Edwards, W.T., Knopf, K.B., and Hayes, W.C., Finite element modeling of failure processes in the skeleton. In: Computational Mechanics (eds. S.N. Atluri and G. Yagawa) Springer-Verlag, Vol. 2 pp 1988

Presentations

• Lotz, J.C., Intervertebral Disc Degeneration and Regeneration. Neurosurgery Grand Rounds, January 13, 2005
• Lotz, J.C., Disc Biology, 2nd Trans Atlantic Spine Congress, Innovations in Spine Surgery, Dallas, November 2004.
• Lotz, J.C., Role of mechanics in disc degeneration and repair/replacement, 5th Combined Meeting of the ORS societies of USA, Canada, Japan and Europe, Banff, Canada, October 2004
• Lotz, J.C., Mechanical regulation of intervertebral disc degeneration and regeneration, SAS 4, Vienna, Austria, May 2004.
• Lotz, J.C., Animal models of intervertebral disc degeneration. Spine Focus Meeting, Chicago, April 2004.
• Lotz, J.C., Hsieh, A, and Bradford. D.S., Mechanical regulation of intervertebral disc degeneration and regeneration, SAS4, Global symposium on intervertebral disc replacement and non-fusion technology, May 2004.
• Lotz, J.C., Mechanobiology of intervertebral disc degeneration. California Physical Therapy Association Chapter Annual Conference, November 2003.
• Lotz, J.C., Tissue engineering the intervertebral disc, 2nd Annual California Tissue Engineering Meeting, San Diego, September, 2003.
• Lotz, J.C., Inflammation and the disc, Spinal Diagnostics and Treatment Meeting, San Francisco, July, 2003.
• Lotz, J.C., and Bradford, D.S., The importance of annular tension in disc repair, The third annual meeting of the Spine Arthroplasty Society, May, 2003
• Rousseau, M-A., Bradford, D.S., and Lotz, J.C., Comparative biomechanics of arthroplasty, The third annual meeting of the Spine Arthroplasty Society, May, 2003
• Lotz, J.C., Biologic Disc Replacement, The third annual meeting of the Spine Arthroplasty Society, May, 2003
• Biomechanical Factors in Disc Degeneration, Biochemical Society, Cardiff England, July 18, 2002
• The Influence of Mechanical Factors on Intervertebral Disc Degeneration, World Conference on Biomechanics, Calgary, August 5, 2002
• Mechanical Regulation of Disc Degeneration, Gordon Research Conference, July 28, 2002
• The Biomechanics of Disc Degeneration, Stanford Biomedical Engineering Seminar Series, May 7, 2001
• Spinal Compression and Disc Degeneration, SYNOS International Symposium on Disc Degeneration, January 18-19, 2001, Berne Switzerland.
• Oh, My Aching Back, UCSF/Mt. Zion Brown Bag Series, 11/00
• Biomechanical and Biological Interactions within the Intervertebral Disc, Orthopaedic Research Day, VA Palo Health Care System Orthopaedics/Stanford University Orthopaedics, December 9, 2000.
• The Biology of Disc Degeneration, Eighth Annual Meeting of the International Spinal Injection Society, September 9, 2000
• An Animal Model for Occupational Exposure and Disc Disease, UCSF Occupational Medicine Research Seminar, July 27, 2000
• Biomechanics and Intervertebral Disc Degeneration, AOS, ABC Exchange Fellowship, San Francisco 2000 Tour, May 24, 2000
• Spinal Disc Physiology, Basic Science Lectures, Department of Neurosurgery, UCSF, January 27, 2000.
• Bi-axial testing of annulus fibrosus - implications for constitutive models, Department of Bioengineering, University of California, San Diego, Nov. 22, 1999
• Relationship between tissue stress and degeneration in the intervertebral disc, Department of Orthopaedic Surgery, University of California, San Diego, Nov. 22, 1999
• Mechanical Loading and Intervertebral Disc Degeneration, American Orthopaedic Association North American Traveling Fellowship 1999 Tour, San Francisco, October 18, 1999.
• The influence of tissue stress on cell activity within the intervertebral disc, International Society of Biomechanics, Calgary August 13, 1999
• Mechanical Stress and Cell Function, Endocrine Grand Rounds, UCSF, October 14, 1998
• Mechanisms of Intervertebral Disc Degeneration, Proctor and Gambles Exploratory Research Program, March 26, 1998.
• Mouse Model for Compression Induced Disc Degeneration, Pre-ORS Intervertebral Disc Repair Think Tank, March 15, 1998.
• Remodeling of Disc and Soft Tissues in the Spine, 20th Annual Engineering Industrial Liaison Conference, University of California at Berkeley, March 11, 1998.
• Mouse Model for Intervertebral Disc Degeneration, Department of Pharmacology, November, 1997
• Your Aching Back: Biomechanics of Intervertebral Disc Degeneration, IDS 114A, UC Berkeley, October 6, 1997
• Distraction Osteogenesis: A Model for Studying the Molecular Basis of Bone Formation in Response to Biomechanical Forces, Grand Rounds, Department of Orthopaedic Surgery, UCSF, December 18, 1996. With Bobby Tay and Jill Helms.
• Poroelastic Analysis of Annulus Fibrosus: Analytical and Experimental Correlations, BE281, Seminars in the Department of Bioengineering, UCSD, November 1, 1996.
• Biomechanics of Femoral Prostheses. Portland Bone Symposium. Portland OR, August, 1995
• A New Liquid Artificial Bone, 1995 Summer Meeting of the Hip Society, June, 27, 1995, San Francisco
• Biomechanics of the Intervertebral Disc: Normal versus Disease. American Academy of Orthopaedic Surgeons, Debating Complex Issues in Spine Surgery, San Francisco, CA, April 5, 1995
• Lumbar Spinal Instability: Fact or Fiction? A Bioengineer's Perspective. American Academy of Orthopaedic Surgeons, Debating Complex Issues in Spine Surgery, San Francisco, CA, April 6, 1995
• The Annulus Fibrosus, the Biologic Fiber Composite. UC Berkeley Bioengineering Seminar, March 7, 1995
• Engineering Aspects of Tissue Remodeling, San Francisco Bone and Mineral Club Seminar Series, June, 7, 1994
• Biomechanics of the Intervertebral Disc, ABC Exchange Traveling Fellows 1994 Tour, UCSF, June, 1994
• Biomechanics of the Intervertebral Disc, Stanford University Bioengineering Seminar, November 29, 1993
• Degeneration of the Intervertebral Disc, UCSF Spine Rounds, November, 17, 1993
• Long Bone Fracture Patterns, UCSF Orthopaedic Surgery Rounds, October, 23, 1993
• Evaluation of Back, Shoulder and Knee Injuries. Fifteenth Annual Meeting of the American Association of Railroads General Claims Conference, Chicago, Illinois, September, 1992.
• The Biomechanics of Lower Extremity Snow Ski Injuries, Ninth International Symposium on Ski Trauma and Skiing Safety, Australia, June 1991.
• The Mechanics of Back Injuries, Spring Meeting of the National Association of Railroad Trial Counsel, Pebble Beach, CA, May 1992.
• Moments and Forces at the Proximal Femur, SOF Pelvic Film Seminar, University of California at San Francisco, July, 1991.
• Biomechanics of Long Bone Fracture Patterns, Stanford University Bioengineering Seminar, February, 1991
• Biomechanics and Forensic Engineering, Stanford University Bioengineering Seminar, May, 1990
• The Effectiveness of Seat Belts in Reducing Injuries: Bioengineering Considerations.: Arizona Trial Lawyers Association Meeting, January, 1989
• Biomechanics of Hip Fractures, 32nd STAPP Car Crash Conference, Atlanta Georgia, October 1988.
• Hip Fracture Risk Predictions by X-ray Computed Tomography, Ph.D. Dissertation Defense, MIT, July, 1988
• Load and Stress Distribution Within the Proximal Femur During Gait and Falls, 1st Annual Health, Science and Technology Forum, MIT, 1987
• Medical Ultrasound - Good Vibrations, American Society of Mechanical Engineers Winter Annual Meeting, November, 1982.

Grants and Awards

• Member, Musculoskeletal Tissue Engineering Study Section, NIH, 2005-2009
• Medtronic Sofamor Danek Best Poster Award, ISSLS Meeting, 2001
• Nordby-Smith Award for Minimally Invasive Surgery, 2000
• National Research Council, Panel on Musculoskeletal Disorders and the Workplace, 1999-2001
• Volvo Award for Low Back Pain Research, 1998
• North American Spine Society AcroMed Award for Outstanding Spinal Research, 1993
• Tau Beta Pi Engineering Honors Fraternity
• Pi Tau Sigma Mechanical Engineering Honors Fraternity
• Howmedica Fellow, 1983-1986
• Whitaker Fellow, 1986-1988

Membership & Committees

• American Society of Mechanical Engineers
• Spine Arthroplasty Society
• North American Spine Society
• International Society for the Study of the Lumbar Spine
• Orthopaedic Research Society

Editorial Boards

• Deputy Editor - Spine
• Associate Editor - The Spine Journal

Reviewer

• Journal of Biomechanical Engineering
• Journal of Biomechanics
• Journal of Bone and Mineral Research
• Journal of Orthopaedic Research