Work is focusing upon development of a novel means of fixation for prostheses devices used to reconstruct skeletal defects in cases of tumor resection and failed arthroplasty. By utilizing a high compression pre-stress concept, this implant seeks to avoid the use of long intramedullary stems and cement that have been associated with stress shielding, osteolysis, and ultimate failure. In contrast, the ComPreSs system provides immediate, rigid fixation that results in bone hypertrophy in response to compression forces. This enhances the success and longevity of limb salvage procedures, especially in young, active individuals. The work is supported by a grant from the Biomet Corporation in Warsaw, Indiana.